| CV-Games: Review, by Daniel Monk Pelfrey: "This game would have been great if it came out 4 years ago." [Grade: D] |
| Electric Playground: Review, by Sean Miller: "Simple or not, it is hard to argue with gameplay this addictive, making Dr. Mario 64 an excellent puzzle gaming purchase, and a perfect method of introducing anyone to the world of console gaming." [Score: 8 out of 10] |
| Game Nation TV: Review, by Kristopher Abel: "It's still a good game, still a good product, but designed chiefly for those who often have friends over to play video games with." |
| Game Revolution: Review, by Johnny Liu: "It's a love or hate affair." [Grade: C] |
| Gaming Age: Review, by Craig Majaski: "Had there been no other competition in this genre Dr. Mario would definitely score higher." [Grade: C-] |
| IGN: Review, by Fran Mirabella III: "Dr. Mario 64 does little to advance forward where the previous version of Mario left off." [Score: 5 out of 10] |
| Nintendojo: Review, by Noah Ward: "There's not too much depth to the strategy of Dr. Mario's simplistic color matching." [Score: 8.5 out of 10] |
| The Adrenaline Vault: Review, by Mike Laidlaw: "The Dr. Mario franchise has never been renowned for its groundbreaking graphics or audio, and Dr. Mario 64 is not an exception to this rule." [Score: 3.5 out of 5] |
| The Armchair Empire: Review, by Omni: "Good addictive fun with friends or alone." |