anygui: The goal of this project is to create an easy-to-use, simple, and generic module for making graphical user interfaces in Python. [Open Source, MIT license]
FXPy: Provides an interface to the FOX GUI library. [Open Source, LGPL]
Pmw: Python meta widgets is a toolkit for building high-level compound widgets in Python using the Tkinter module. [Open Source, MIT license]
pygame: A set of Python extension modules designed for writing games. The core of pygame is wrapped on top of the SDL library. [Open Source, LGPL]
PyGTK: Python bindings for the GTK widget set. [Open Source, LGPL]
PyKDE: Python bindings for the KDE desktop environment. [Open Source, BSD-like]
PyQt: Contains Python bindings for the Qt GUI toolkit. [Open Source, BSD-like]
Python X Library: Pure Python interface to X Window system. [Open Source, GPL]
PythonCard: A software construction kit built in, and using, Python. Its purpose is to allow you to easily and quickly build graphical applications. [Open Source, Python license]
SpecTix GUI Builder: SpecTix provides a development environment to build applications with graphical user interfaces that run on multiple platforms with multiple languages, including Tcl, Python and Ruby.
The Dabo Framework: A 3-tier, cross-platform application development framework, written in Python atop the wxPython GUI toolkit. [Open source, MIT license]
Tix: The Tk Interface eXtension is a set of GUI components that enhance the appearance and functionality of your Tkinter applications. [Open Source, BSD-like]
Tix Applications Framework: Tixapps applications are a suite of development applications that run with Tk/Tcl or Python using the Tix widget set. Applications currently included are: tixinspect - an inspector for Tix/Tk applications; tixdebug - a debugger to work with tixinspect; and tixinfo - an info browser for GNU documentation.
Tkinter3000 Widget Construction Kit: Tkinter3000 is a Widget Construction Kit that allows you to write new Tkinter widgets in Python using Mixins. [Open Source, BSD-like]
wxPython: A popular cross-platform Python GUI toolkit for Windows and Unix with native look and feel on each platform. [Open Source, LGPL]
xdialog: A wrapper for the Xdialog program that encapsulates the details of calling Xdialog and getting return values. [Open Source, LGPL]