| I'm Blue: Highlights the trials, tribulations and comedy of the main character Blue Veers, and her friends Celia, Derec, Tyger, Max, and Duo. |
| Ida Arts: A gallery of cartoons about a misfortunate cat named Cas. |
| Idiom Syndrome: A photo-webcomic with random humour for the most part. |
| If Dinosaurs Could Fly Helicopters: Offers about, cartoons, jokes and a gallery. |
| Ignaki: A collection of cartoons about food, computers, art; translated into English. By Ignacio Lafferriere. |
| In Real Life: Following the adventures of Mario, Mega Man, and Link when they are sucked out of the Super NES. |
| In the Bleachers: Steve Moore's syndicated humor cartoon about sports. |
| In the Dark: Demons and Angels. Where the battle to free Demonkind from the Netherworld is about to break out. By Alex. |
| Inepto.com: Lampoons ineptitude at all levels of society, from customer service to CEOs and politicians. |
| Ink: A comic strip about a full-time father/part-time cartoonist and his family. By Jason Milfred. |
| Ink On Paper: We've got Magic Pig, Supa Fly, Bob Quackers and more strips. |
| Inktank.com: Two strips: Angst Technology, about a game development company, and Weak-end Warriors, about paintball. |
| Innies and Outties: Funny comic strip about two latchkey kids imagining their way through the enchanted land of suburbia. By Leonard Cachola. |
| Insane Add-a-Panel: Add a panel to this comic. An always changing comic. |
| Insane Comics: A normal sprite comic site but with a twist. Include Super Heroes In Training, Unit 003, 8 Bit Insanity, and Megaman SC. |
| Inside The Box: A collection of the comics and art by Marlowe Leverette. |
| Intelligent Humor: Offbeat comic, also known as "Big Meaty Chunks", by Chris Williams. Collected by Steven Dengler of Xenon Labs. |
| Interns: Features three interns as they work at a prominent comic book publisher. Includes character bios. |
| Intershadows: Features an archive of the title, a gallery of sketches and illustrations, and the series Coolville. By Kathleen Jacques. |
| Irregular Webcomic!: Lego and gaming photo comics by David Morgan-Mar. |
| Irrelevant: Contains quizes, polls and such, as well as the weekly toon. |
| Is This Tomorrow?: Features collections, a history, and archives of various strips. Created by Kelly Shane & Woody Compton. |
| Isk: A web comic about a small tormented child. |
| Isometric: A comic strip drawn entirely with isometric perspective cubes. |
| It Could Happen: A comic strip which takes a unique and entertaining look into the life of a home schooling family. By Gail Anne. |
| It Happens Every Day ...: Weekly family comic strip featuring the lives of the Brenner family. by Sonia Oppenheim. |
| It's a Crock: A weekly cartoon about some of the absurdities of everyday life in America. The cartoon features Cloe and Ocks the Albino Crocks. |
| The Imp: A humor strip about hell, by Jose Arroyo and Robin Reed. |
| The Infirm: Humor comic about a first-year associate attorney. |
| The Invisible Life of Poet: Social commentary through the eyes of a child. By Christopher Wilson. |
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